Fibrinogen Replacement Calculator
Calculate fibrinogen concentrate dose from viscoelastic test results (ROTEM FIBTEM, TEG CFF-MA, Quantra FCS). Includes weight-adjusted dosing, cryoprecipitate conversion, and clinical target profiles for perioperative hemorrhage.
Based on: ESC 2022 · ESAIC
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How this calculator works
What this calculator does
This calculator estimates the amount of fibrinogen concentrate required to raise plasma fibrinogen to a desired target level. The calculation is based on body weight, the current fibrinogen level, and a correction factor that approximates plasma volume.
What target profiles mean
The target profiles represent practical correction goals used in different clinical settings. They are not universal treatment triggers. Clinical decisions should always consider bleeding severity, surgical context, and viscoelastic testing when available.
Why 200 vs 300 mg/dL? → Learn More
About the correction factor
The default value (2500) is appropriate for most adult patients. Body weight already reflects estimated plasma volume; the correction factor is an optional adjustment for clinical variability such as haemodilution or ongoing bleeding. It can be changed under Advanced settings if needed.
Why 2500 — and when to adjust? → Learn More
Safe use reminder
This calculator provides an estimate only. Clinical judgement and reassessment with laboratory or viscoelastic testing are essential after fibrinogen replacement.
Overview
This standalone calculator is lab-first: the primary input is laboratory fibrinogen (Clauss assay, mg/dL). Fibrinogen is the first coagulation factor to become critically depleted during major haemorrhage. Enter the measured lab value, select a clinical target profile, and the calculator estimates the replacement dose. Approximate ROTEM, TEG, and Quantra equivalents are shown as secondary cross-checks after calculation.
Evidence Summary
Prospective data and perioperative guidelines support early, targeted fibrinogen replacement in cardiac surgery, trauma, liver transplantation, and major obstetric haemorrhage. The lab-based dose formula — (target − measured fibrinogen) × weight ÷ correction factor — is a weight-adjusted estimate based on plasma volume (~40 mL/kg). Target profiles in this calculator represent practical correction targets; actual treatment triggers depend on clinical context and institutional protocol. Early fibrinogen replacement reduces allogeneic transfusion requirements and may improve outcomes in cardiac surgery (Innerhofer, 2017) and massive haemorrhage (FEISTY, 2021).