Fibrinogen Replacement Calculator
Calculate fibrinogen concentrate dose from viscoelastic test results (ROTEM FIBTEM, TEG CFF-MA, Quantra FCS) for perioperative bleeding management. Weight-adjusted dosing, cryoprecipitate conversion, and target profiles for cardiac surgery, trauma, and obstetric hemorrhage.
Based on: ESC 2022 · ESAIC
Clinical decision support for perioperative care. · About this platform
Input
Fibrinogen replacement dose
Estimate fibrinogen concentrate, cryoprecipitate, and FFP equivalents.
Parameter input
Platelet replacement estimate
Estimate platelet units from platelet count, body weight, and selected target.
Overview
This standalone calculator is lab-first: the primary input is laboratory fibrinogen (Clauss assay, mg/dL). Fibrinogen is the first coagulation factor to become critically depleted during major haemorrhage. Enter the measured lab value, select a clinical target profile, and the calculator estimates the replacement dose. Approximate ROTEM, TEG, and Quantra equivalents are shown as secondary cross-checks after calculation.
Evidence Summary
Prospective data and perioperative guidelines support early, targeted fibrinogen replacement in cardiac surgery, trauma, liver transplantation, and major obstetric haemorrhage. The lab-based dose formula — (target − measured fibrinogen) × weight ÷ correction factor — is a weight-adjusted estimate based on plasma volume (~40 mL/kg). Target profiles in this calculator represent practical correction targets; actual treatment triggers depend on clinical context and institutional protocol. Early fibrinogen replacement reduces allogeneic transfusion requirements and may improve outcomes in cardiac surgery (Innerhofer, 2017) and massive haemorrhage (FEISTY, 2021).
Learn More
Learn the coagulation patterns
Review how fibrinogen deficiency appears across ROTEM, TEG 6s, and Quantra, and how replacement thresholds differ by device. Use the education guide to confirm clinical decision thresholds.